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Biopsy forceps are available as cup biopsy forceps and as punch biopsy forceps (ssss1). Punch biopsy forceps will cut tissue as one jaw “punches” through the fenestration in the opposite jaw. On the other hand, cup biopsy forceps provide some hemostasis by crushing and tearing tissues at the edges of the biopsy sample as the cup is closed and then gently twisted to obtain the specimen. Some cup biopsy instruments have a fine spike in one or both jaws to better secure tissue; however, this spike is not necessary to obtain adequate tissue samples for histologic analysis. In our practice, cup biopsy forceps are the most commonly used biopsy instrument for obtaining liver, splenic, pancreatic, adrenal, lymph node, and other soft tissue mass biopsies. Because punch biopsy forceps cut rather than tear, they may be more appropriate for use in tissues such as the pancreas, where tearing may incite inflammation and pancreatitis. Biopsy forceps can also be on either a ratcheted or nonratcheted handle; however, ratcheted handles allow for a better, more consistent grip on tissues while obtaining a biopsy sample.