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In November, 1795, Frank returned to Vienna and was almost immediately appointed Director of the Allgemeine Krankenhaus and Professor of the Medical Clinic with a salary of 5,000 florins and the privilege of occupying rent-free a house that was located in the immediate neighborhood of the hospital. At the same time the title of Aulic Councillor (Hofrath) was conferred upon him. One of the first improvements which he effected in the clinic was to have the small wards for male and female patients materially enlarged so that when twenty-five or thirty patients were present, as was often the case, the air might not become noticeably contaminated and thus rendered unfit for all who were present to breathe.

In his teaching Frank never forgot, on all possible occasions, to impress upon the students the importance of thinking independently on the subjects that were brought before them, as in this way they would learn to distinguish the false from the true. Whenever he discovered that he had made a mistake in one of his statements he did not hesitate to confess the fact. His son, Joseph, is responsible for the statement that his father never seemed to him happier than when he had an opportunity of making to his auditors some such speech as the following: “Gentlemen! Strike out this or that line in one of the volumes of my work! When I wrote it I believed that it was correct; but now I am convinced that the very opposite is the truth!” When Brunonianism was first transplanted from Great Britain to the Continent and was received enthusiastically by many physicians, Frank was not disposed immediately to accept its teachings, and yet at the same time he did not believe that it was quite fair to ignore the thing altogether. Not a few men inferred from this hesitating attitude on his part that he rather favored Brown’s system. As a matter of fact he was an eclectic in his views and was always ready to appropriate whatever seemed to him good in any system or school of doctrines. As Director of the Allgemeine Krankenhaus he adopted the plan of having the leading physicians and surgeons of the Clinic first report publicly once a week what were the important diseases that had come under observation during that period; and then he would call upon the auditors to discuss the subject freely.