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This conclusion obviously follows from it, that difference of weight in different substances arises not from one having more molecules in the same volume than another, but from the molecules themselves being heavier. If we weigh a gallon or litre of hydrogen gas, which is the lightest known substance, and then weighing an equal volume of oxygen gas find that it is sixteen times heavier, we know for certain that the molecule or ultimate particle of oxygen is sixteen times heavier than that of hydrogen.

It is evident that in this way the molecules of all simple substances which can exist in the form of pure gas can be weighed, and their weight expressed in terms of the unit which is generally adopted, that of the molecule of the lightest known substance, hydrogen. But science, not content with this achievement, wants to know not the relative weight only, but the absolute dimensions, qualities, and motions of these little bodies; and whether, although they cannot be divided further by mechanical means, and while retaining the qualities of the substances they build up, they are really ultimate and indivisible particles or themselves composites.