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With respect to the Modus Operandi of medicines the following classification may be established.

The Particular Organs of the Body may be excited into action, through four distinct and different modes of communication. I. By the actual contact of the appropriate remedy. 1. Conveyed by absorption, WITHOUT DECOMPOSITION. Internally. a. through the branches of the Thoracic duct. b. through the branches of the Vena Portarum.^[132] Externally. c. through the branches of divided blood-vessels. d. through the branches of Lymphatics.^[133] 2. Conveyed by absorption, WITH DECOMPOSITION, by which one or more of its constituents are developed, and pass into the circulating current. II. By an impulse conveyed through the instrumentality of the nerves. III. By the sympathetic control exerted by the stomach on distant parts. IV. By the operation of contiguous sympathy, or of that which is excited by the mere proximity and continuity of parts.

And it is important to observe, that these are frequently antagonist operations, and consequently, that remedies, although they should occasion the same apparent effects, unless they act through the same medium, are not SIMILAR agents, but on the contrary, are generally medicinally incompatible with each other; for an illustration of this truth, the practitioner may refer to the observations which I have offered under the history of diuretics.