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Symptoms similar to fever have also been produced in animals by thyroid feeding; thus, very often elevation of the frequency of the pulse from 100 to 140-160 beats (Lanz), and from 150 to 200 beats (Georgiewski), while Ballet and Enriquez^[70] produced regular fever in their animals; Easterbrook^[71] also produced “some pyrexia” in his animals and an increase of pulse-rate of about 40 a minute. As Dr. Tanberg, former assistant of the Physiological Institute in Christiania, told us, he has produced an increase of the temperature of two and a half degrees in animals, whose thyroid he had extirpated, after giving very large quantities of thyroid gland.

It is of great interest to the question at issue that the remedies which we employ to fight fever should also produce symptoms like the thyroid does when it is in increased activity. Thus salicylates produce a vaso-dilatation and abundant perspiration, and afterward diminution of the temperature. We have, ourself, taken salicylates or acetonitril preparation and felt the sensation of heat and afterward perspiration. When we take a hot air or steam bath for cold or gouty pains we produce first, great heat, tachycardia, and then abundant perspiration, and the typical symptoms of fever or increased thyroid activity.