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P. Muller also declares that there are intimate relations between the sexual glands and the digestive organs. He also observed dyspeptic troubles during menstruation; and Professor Leyden has noted neuralgia and hyperæsthesia of the stomach in young girls after menstrual troubles.

Habitual chronic constipation, which is so frequent after a degenerated condition of the sexual glands, points to the existence of close relations between these organs and the intestines.

Based upon clinical observations, we have advanced the theory that alterations of the ovaries are able to produce alterations also of the liver, and the circulation of the bile, with formation of gall-stones. Castration also produces alterations of the thyroid: first, its hyperactivity with increase of colloid substance, and, afterward, its degeneration.

Castrated animals or persons seem to offer less resistance to infection, which may be on account of the connection, as shown by the experiments of Metschnikoff^[103] and others, that the testicles are altered in infections, which has been shown to be equally the case with the ovaries (Professor Cornil). The sexual glands, as the ductless glands in general, have the duty also of protecting the body against the various kinds of intoxication and infections, as already emphasized.