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The limited influence of the internal secretions of the sexual glands in forming the sexual characters must be realised to warrant the theory of a primary, generally slight, difference in each cell, but still determinate sexual influence.ssss1 If the existence of distinct graduations of these primary characteristics in all the cells and tissues can be recognised, there follow many important and far-reaching conclusions. The individual egg-cells and spermatozoa may be found to possess different degrees of maleness and femaleness, not only in different individuals, but in the ovaries and testes of the same individual, especially at different times; for instance, the spermatozoa differ in size and activity. We are still quite ignorant on these matters, as no one has worked on the requisite lines.

ssss1 The existence of sexual distinctions before puberty shows that the power of the internal secretions of the sexual glands does not account for everything.

It is extremely interesting to recall in this connection that many times different investigators have observed in the testes of amphibia not only the different stages in the development of spermatozoa, but mature eggs. This interpretation of the observations was at first disputed, and it was suggested that the presence of unusually large cells in the tubes of the testes had given rise to the error, but the matter has now been fully confirmed. Moreover, in these Amphibia, sexually intermediate conditions are very common, and this should lead us to be careful in making statements as to the uniform presence of arrhenoplasm or thelyplasm in a body. The methods of assigning sex to a new-born infant seem most unsatisfactory in the light of these facts. If the child is observed to possess a male organ, even although there may be complete epi- or hypo-spadism, or a double failure of descent of the testes, it is at once described as a boy and is henceforth treated as one, although in other parts of the body, for instance in the brain, the sexual determinant may be much nearer thelyplasm than arrhenoplasm. The sooner a more exact method of sex discrimination is insisted upon the better.


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