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The facts hitherto collected upon this subject are so scanty and unsatisfactory, that I introduce its consideration in this place, rather with a wish to excite farther enquiry, than with any hope of imparting much additional information.

There can be little doubt, but that Soil, Culture, Climate, and Season,^[118] may very materially influence the active properties of a medicinal plant; while the two latter of these causes may as essentially change the type and character of a disease, and modify the vital susceptibility of the patient; the natives of the south of Europe, for instance, do not bear bleeding, and other modes of depletion, so well as those of the north. This must be admitted to its full extent, or it will be extremely difficult to explain the contradictory and even opposite opinions, and to reconcile the conflicting testimonies of the physicians of different countries, with respect to the efficacy of the same remedy, in similar diseases.