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What brings misery to a founder? Competition? Lack of financing? Market acceptance of product? Or the inability to do a hundred small things required each day?

Stressful life events have a substantial relationship with the onset of episodes of major depression, researchers proclaim, as seen in ssss1. A start-up life includes a generous dose of depressive triggers; loss of job occurs by design or default. There is neither a financial cushion nor a predictable drip of a salary each month. All founders have faced financial problems, be it personal or be it payroll. Or legal hassles. Marital challenges are not too far behind.

individuals predisposed to major depression select themselves into high-risk environments

External Events and Depression Triggers

Life Events Odds that such events trigger depression Month of event Three months after the event Job loss 3.95 N/A Legal problems 3.81 10.81 Work problems 2.44 2.74 Financial problems 5.85 2.36 Divorce 5.22 N/A Marital problems 8.39 4.29 Assault 25.36 N/A

(Source: K. S. Kendler, J. Kuhn, and C. A. Prescott, “The Interrelationship of Neuroticism, Sex, and Stressful Life Events in the Prediction of Episodes of Major Depression,” American Journal of Psychiatry 161, no. 4 (2004): 631–636.)