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This boy had been transfused for therapeutic purposes; the second transfusion performed by Denys was done upon an older man “having no considerable indisposition,” and was purely experimental. About twenty ounces of lamb’s blood are stated to have been transfused, but the procedure was without any ill effect, and it may be doubted whether the man received as much as this.

In the succeeding number of the Philosophical Transactions, October 21, 1667, the remarks of another French experimenter, Gaspar de Gurye, are quoted. These are of considerable interest, as they contain the first warning of the dangers attending the administration of incompatible blood. De Gurye affirms “that an expert Acquaintance of his, transfusing a great quantity of blood into several Doggs, observed alwayes, that the Receiving Doggs pissed Blood.”

Other cases were subsequently recorded by Denys. In one he claims to have cured a patient suffering from “an inveterate Phrenzy.” His account of it is too long to be quoted here in full, but it is of special interest in that it contains the first account of hæmolysis and the attendant symptoms in man which follow the transfusion of incompatible blood. The blood of a calf was used in this instance and on two occasions; at the first transfusion only a small amount was given, but at the second,